Kini Hydroxypropyl methyl cellulose HPMC?

Hydroxypropyl methyl cellulose HPMC jẹ ti kii-ionic cellulose adalu ether ni orisirisi kan ati ionic methyl carboxymethyl cellulose adalu ether, o ko ni fesi pẹlu eru awọn irin. Awọn ipilẹṣẹ atẹgun kan nitori akoonu hydroxypropyl methyl cellulose ati ipin oriṣiriṣi ti akoonu hydroxypropyl ati iki, di awọn oriṣiriṣi oriṣiriṣi lori iṣẹ ṣiṣe, fun apẹẹrẹ, akoonu methoxyl giga ati akoonu kekere ti awọn orisirisi hydroxypropyl, iṣẹ ṣiṣe rẹ sunmọ methyl cellulose ati methoxyl kekere. akoonu ati akoonu giga ti awọn orisirisi hydroxypropyl, ati pe iṣẹ rẹ sunmo si hydroxypropyl methyl cellulose ti wa ni iṣelọpọ. Ṣugbọn ni oriṣiriṣi kọọkan, botilẹjẹpe nikan ni iye kekere ti hydroxypropyl tabi iwọn kekere ti methoxy, solubility ni awọn olomi Organic tabi iwọn otutu flocculation ni ojutu olomi, iyatọ nla wa.
 
1, hydroxypropyl methyl cellulose solubility
Hydroxypropyl methyl cellulose ninu omi solubility ti hydroxypropyl methyl cellulose jẹ kosi kan irú ti propylene oxide (methyl oxypropyl oruka) títúnṣe methyl cellulose, ki o si tun ni o ni iru pẹlu methyl cellulose tutu omi tiotuka ati ki o gbona omi insoluble abuda. Sibẹsibẹ, iwọn otutu gelation ti hydroxy propyl ti a ṣe atunṣe ga pupọ ju ti methyl cellulose ninu omi gbona. Fun apẹẹrẹ, iki ti hydroxypropyl methylcellulose ojutu olomi pẹlu 2% methoxy akoonu DS=0.73 ati hydroxypropyl akoonu MS=0.46 jẹ 500 mpa ni 20℃. Iwọn jeli ti ọja S jẹ isunmọ si 100 ℃, lakoko ti ti methyl cellulose ti iwọn otutu kanna jẹ nipa 55 ℃. Bi fun awọn oniwe-solubility ninu omi, tun gidigidi dara si, fun apẹẹrẹ, lẹhin fifun pa hydroxypropyl methylcellulose (ọkà apẹrẹ 0.2 ~ 0.5mm ni 20℃ 4% olomi iki ti 2pA? S awọn ọja le wa ni awọn iṣọrọ ni tituka ninu omi lai itutu agbaiye ni yara otutu. .
 
(2) Hydroxypropyl methyl cellulose ni Organic solvents solubility ti hydroxypropyl methyl cellulose ni Organic solvents solubility, jẹ tun dara ju methyl cellulose, methyl cellulose nilo ni methoxy aropo ìyí ti 2.1 tabi diẹ ẹ sii awọn ọja, ati ki o ni hydroxypropyl MS=1.5 ~ 1.8 ati methoxypropyl. DS=0.2 ~ 1.0, Giga viscosity hydroxypropyl methyl cellulose pẹlu lapapọ aropo ìyí loke 1.8 jẹ tiotuka ni anhydrous kẹmika ati ethanol solusan, ati ki o ni thermoplastic ati omi solubility. O tun jẹ tiotuka ninu awọn hydrocarbons chlorinated gẹgẹbi dichloromethane ati trichloromethane, ati awọn nkanmimu Organic gẹgẹbi acetone, ọti isopropyl, ati ọti diacetone. Solubility rẹ ni awọn nkan ti o nfo Organic jẹ ti o ga ju omi solubility lọ.
 
2, hydroxypropyl methyl cellulose viscosity ti awọn okunfa ipa
Awọn ifosiwewe viscosity Hydroxypropyl methylcellulose hydroxypropyl methylcellulose boṣewa viscosity ipinnu, ati awọn miiran cellulose ether jẹ kanna, ni 20℃ pẹlu 2% olomi ojutu bi awọn boṣewa ipinnu. Itọka ti ọja kanna, pẹlu ilosoke ti ifọkansi ati ilosoke, ifọkansi kanna ti awọn ọja iwuwo molikula oriṣiriṣi, iwuwo molikula ti ọja jẹ iki giga. Ibasepo rẹ pẹlu iwọn otutu jẹ iru si ti methyl cellulose. Nigbati iwọn otutu ba dide, iki bẹrẹ lati kọ silẹ, ṣugbọn nigbati o ba de iwọn otutu kan, iki yoo dide lojiji ati gelation waye. Awọn iwọn otutu gelation ti awọn ọja pẹlu iki kekere jẹ ti o ga ju ti awọn ọja pẹlu iki giga. Ipele ti aaye gel rẹ, ni afikun si iki giga ati kekere ti ether, ṣugbọn pẹlu pẹlu methoxy ether ati ipin akojọpọ ẹgbẹ hydroxypropyl ati iwọn aropo lapapọ jẹ ibatan. O gbọdọ ṣe akiyesi pe hydroxypropyl methylcellulose tun jẹ pseudoplastic; ojutu rẹ jẹ iduroṣinṣin nigbati o ba fipamọ ni iwọn otutu yara ati pe ko ṣe afihan eyikeyi ibajẹ ti iki ayafi fun iṣeeṣe ibajẹ enzymatic.
 
3, hydroxypropyl methyl cellulose acid ati ipilẹ resistance
Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid ati alkali, ni gbogbogbo jẹ iduroṣinṣin, ni iwọn ph PH2 ~ 12 ko ni ipa, o le duro ni iye kan ti acid ina, gẹgẹbi formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, bbl Ṣugbọn acid ogidi ni ipa ti idinku iki. Alkali gẹgẹbi omi onisuga caustic, potasiomu caustic ati omi orombo wewe ko ni ipa lori rẹ, ṣugbọn ipa ti jijẹ iki diẹ ti ojutu yoo dinku laiyara ni ojo iwaju.
 
4, hydroxypropyl methyl cellulose le jẹ adalu
Hydroxypropyl methyl cellulose ojutu le jẹ adalu pẹlu omi-tiotuka polima agbo, ati ki o di a aṣọ sihin ojutu pẹlu ga iki. Awọn agbo ogun molikula giga wọnyi jẹ polyethylene glycol, polyvinyl acetate, polysilicon, polymethyl vinyl siloxane ati hydroxyethyl cellulose ati methyl cellulose, bbl. ojutu. Hydroxypropyl methyl cellulose tun le dapọ pẹlu stearic acid tabi palmitic acid mannitol ester tabi sorbitol ester, ṣugbọn pẹlu glycerol, sorbitol ati mannitol, awọn agbo ogun wọnyi le ṣee lo bi hydroxypropyl methyl cellulose plasticizer.
 
5, hydroxypropyl methyl cellulose insoluble omi tiotuka
Hydroxypropyl methyl cellulose insoluble omi-tiotuka cellulose ether, le jẹ dada agbelebu-asopo pẹlu aldehydes, ki o si ṣe awọn wọnyi omi-tiotuka ether precipitated ni ojutu, di insoluble ninu omi. Ati ṣe hydroxypropyl methylcellulose aldehyde insoluble aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, ati bẹbẹ lọ, lilo formaldehyde yẹ ki o san ifojusi pataki si iye PH ti ojutu, ninu eyiti ifaseyin glioxal yiyara, nitorinaa ni iṣelọpọ ile-iṣẹ ti o wọpọ lo glioxal bi agbelebu. -sisopọ oluranlowo. Iwọn ti iru oluranlowo crosslinking ni ojutu jẹ 0.2% ~ 10% ti ether mass, ti o dara julọ jẹ 7% ~ 10%, gẹgẹbi lilo glioxal pẹlu 3.3% ~ 6% jẹ eyiti o yẹ julọ. Iwọn otutu itọju gbogbogbo jẹ 0 ~ 30 ℃, akoko jẹ 1 ~ 120min. Idahun sisopọ agbelebu nilo lati ṣe labẹ awọn ipo ekikan. Ni gbogbogbo, inorganic lagbara acid tabi Organic carboxylic acid ti wa ni afikun si ojutu lati ṣatunṣe PH ti ojutu si nipa 2 ~ 6, ni pataki laarin 4 ~ 6, ati lẹhinna a ṣafikun aldehydes fun iṣesi ọna asopọ agbelebu. Awọn acids ti a lo ni hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid tabi citric acid, laarin eyiti formic acid tabi acetic acid jẹ ti o dara julọ, nigba ti formic acid jẹ ti o dara julọ. Awọn acids ati aldehydes le tun ṣe afikun ni akoko kanna lati jẹ ki ojutu naa jẹ ọna asopọ agbelebu ni ibiti PH ti o fẹ. Ihuwasi yii ni igbagbogbo lo ni ilana ikẹhin ti ilana igbaradi cellulose ether, ki ether cellulose ko ni tu, rọrun lati lo 20 ~ 25 ℃ omi lati wẹ ati sọ di mimọ. Nigbati o ba ti lo ọja naa, awọn oludoti ipilẹ le ṣe afikun si ojutu ọja lati ṣatunṣe PH ti ojutu lati jẹ ipilẹ, ati pe ọja naa yarayara ni tituka ni ojutu. Ọna yii tun le ṣee lo nigbati ojutu ether cellulose ti lo lati ṣe fiimu kan ati lẹhinna a ṣe itọju fiimu naa lati ṣe fiimu ti a ko le yanju.
 
6, hydroxypropyl methyl cellulose egboogi-enzyme
Hydroxypropyl methyl cellulose henensiamu resistance ti awọn itọsẹ cellulose ni yii, gẹgẹ bi awọn ẹgbẹ anhydroglucose kọọkan gẹgẹbi apapo to lagbara ti awọn ẹgbẹ ti o rọpo, ogbara ti microorganisms ko ni ifaragba si ikolu, ṣugbọn ni otitọ ọja ti pari lati rọpo iye diẹ sii ju 1, tun nipasẹ ibajẹ henensiamu, eyi ni apejuwe ti ẹgbẹ kọọkan ninu alefa fidipo pq cellulose kii ṣe aṣọ, Awọn microorganisms le bajẹ nitosi awọn ẹgbẹ glukosi ti o gbẹ ti ko rọpo lati ṣe awọn suga, eyiti o le gba nipasẹ awọn microorganisms bi ounjẹ. Nitorinaa, ti iwọn aropo etherification ti cellulose ba pọ si, resistance ti ether cellulose si ogbara enzymatic yoo ni ilọsiwaju. O royin pe labẹ awọn ipo iṣakoso, iki ti o ku ti hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), ati hydroxyethyl cellulose (1.7%) jẹ 13.2%, 7.3% , 3.8%, ati 1.7%, lẹsẹsẹ. Hydroxypropyl methyl cellulose ni agbara egboogi-enzyme to lagbara. Nitorinaa hydroxypropyl methylcellulose anti-enzyme ti o dara julọ, ni idapo pẹlu pipinka ti o dara, ti o nipọn ati iṣelọpọ fiimu, ti a lo ninu awọn aṣọ emulsion, ati bẹbẹ lọ, ni gbogbogbo ko nilo lati ṣafikun awọn olutọju. Sibẹsibẹ, lati le ṣe idiwọ ibi ipamọ igba pipẹ ti ojutu tabi ibajẹ ti o ṣee ṣe lati ita ita, a le ṣafikun awọn ohun-itọju, ti yiyan rẹ le pinnu ni ibamu si awọn ibeere ikẹhin ti ojutu. Phenylmercuric acetate ati manganese fluosilicate jẹ awọn itọju ti o munadoko, ṣugbọn wọn jẹ majele ati pe o gbọdọ ṣiṣẹ ni pẹkipẹki. Ni gbogbogbo, 1 ~ 5mg phenylmercuric acetate le ṣe afikun si lita kọọkan ti ojutu.
 
7, hydroxypropyl methyl cellulose awo awọ iṣẹ
Hydroxypropyl methyl cellulose film išẹ ti hydroxypropyl methyl cellulose ni o ni o tayọ film, awọn oniwe-olomi ojutu tabi Organic epo ojutu, ti a bo lori gilasi awo, lẹhin gbigbe di colorless, sihin ati alakikanju fiimu. O ni resistance ọrinrin to dara ati pe o wa ni ri to ni awọn iwọn otutu giga. Bii afikun ti ṣiṣu ṣiṣu hygroscopic, le ṣe alekun elongation ati irọrun rẹ, lati mu irọrun dara, glycerol ati sorbitol ati ṣiṣu ṣiṣu miiran jẹ eyiti o yẹ julọ. Ifojusi ojutu gbogbogbo jẹ 2% ~ 3%, iwọn lilo plasticizer jẹ 10% ~ 20% ti ether cellulose. Ti o ba jẹ pe akoonu ti ṣiṣu ṣiṣu jẹ itunnu, iṣẹlẹ isunku ti gbigbẹ colloid le waye ni ọriniinitutu giga. Agbara fifẹ ti fiimu ti a fi kun ṣiṣu jẹ tobi pupọ ju eyiti a ko fi kun, ati pe o pọ si pẹlu ilosoke iye ti a fi kun, bi fun hygroscopicity ti fiimu naa tun pọ si pẹlu ilosoke iye ti plasticizer.